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Bioinformatics

The bioinformatics lab at the Technical University of Munich, TUM Campus Straubing for Biotechnology and Sustainability is led by Prof. Dr. Dominik Grimm from the University of Applied Sciences Weihenstephan-Triesdorf. 

Bioinformatics is a young interdisciplinary research area that develops computational and statistical tools to analyze, store, integrate and visualize biological and biomedical data. One of the main research areas of our group is the development and usage of novel computational tools and machine learning methods to gain a deeper understanding of the underlying genetic architecture of complex biological processes and phenotypes. In addition, we are interested in developing efficient pipelines and applications to process and analyze Next Generation Sequencing (NGS) data. Further, we develop modern cloud-based applications and databases to simplify the analysis, storage, retrieval and visualization of diverse and complex biological and biomedical data.

Software & Resources

easyGWAS

 easyGWAS is a novel web- and cloud platform for performing, analysing and comparing  genome-wide association studies (GWAS).

The AraGWAS Catalog

The AraGWAS Catalog is a public and manually curated database for standardised GWAS results for Arabidopsis thaliana.

AraPheno

AraPheno is a central and public repository of high-quality Arabidopsis thaliana phenotypes.

Software & Methods

Software and Methods developed by the group can be found and downloaded at our Github repository.

Lab News

New Publication in Bioinformatics

New Publication in Bioinformatics

New publication about “Network-guided search for genetic heterogeneity between gene pairs” just got published in Bioinformatics: https://academic.oup.com/bioinformatics/advance-article/doi/10.1093/bioinformatics/btaa581/5861532

We propose a novel method for finding pairs of interacting genes that are, upon combination, associated with a phenotype of interest under a model of genetic heterogeneity. We guide the interaction search using biological prior knowledge in the form of protein-protein interaction networks. Our method controls type I error and outperforms state-of-the-art methods with respect to statistical power. Additionally, we find novel associations for multiple A. thaliana phenotypes, and for a study of rare variants in migraine patients.

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Wissenschaftler sagen Tulpen-Müllbergen den Kampf an

Wissenschaftler sagen Tulpen-Müllbergen den Kampf an

Zierpflanzen, Stauden oder Schnittblumen sind hierzulande extrem beliebt, vor allem in der Woche vor Muttertag brummt das Geschäft. Dieses Jahr allerdings ist die Nachfrage nach Blumenschmuck oder Sträußen trotz Muttertag eingebrochen, weil aufgrund der Corona-Pandemie viele Veranstaltungen wie Hochzeiten abgesagt wurden. Das Problem, dass die Nachfrage nach gärtnerischen Produkten stark von externen Faktoren wie Witterung, Feiertagen, regionalen Veranstaltungen oder anderen – oftmals noch unbekannten – Einflussfaktoren abhängig ist, besteht für viele Wertschöpfungsketten im Gartenbau.

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Kontakt

Professorship Bioinformatics

Petersgasse 18
94315 Straubing

Head

Prof. Dr. Dominik Grimm

Phone: +49 (0) 9421 187-230
Fax: +49 (0) 9421 187-285
E-Mail: dominik.grimm@hswt.de

Team Assistent

Ingrid Meindl

Phone: +49 (0) 9421 187-271
Fax: +49 (0) 9421 187-285
E-Mail: ingrid.meindl@hswt.de

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