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Bioinformatics

The bioinformatics lab at the Technical University of Munich, TUM Campus Straubing for Biotechnology and Sustainability is led by Prof. Dr. Dominik Grimm from the University of Applied Sciences Weihenstephan-Triesdorf. 

Bioinformatics is a young interdisciplinary research area that develops computational and statistical tools to analyze, store, integrate and visualize biological and biomedical data. One of the main research areas of our group is the development and usage of novel computational tools and machine learning methods to gain a deeper understanding of the underlying genetic architecture of complex biological processes and phenotypes. In addition, we are interested in developing efficient pipelines and applications to process and analyze Next Generation Sequencing (NGS) data. Further, we develop modern cloud-based applications and databases to simplify the analysis, storage, retrieval and visualization of diverse and complex biological and biomedical data.

Software & Resources

easyGWAS

 easyGWAS is a novel web- and cloud platform for performing, analysing and comparing  genome-wide association studies (GWAS).

The AraGWAS Catalog

The AraGWAS Catalog is a public and manually curated database for standardised GWAS results for Arabidopsis thaliana.

AraPheno

AraPheno is a central and public repository of high-quality Arabidopsis thaliana phenotypes.

Software & Methods

Software and Methods developed by the group can be found and downloaded at our Github repository.

Lab News

New Paper: Systematic analysis of the underlying genomic architecture for transcriptional–translational coupling in prokaryotes

New Paper: Systematic analysis of the underlying genomic architecture for transcriptional–translational coupling in prokaryotes

New paper about “Systematic analysis of the underlying genomic architecture for transcriptional–translational coupling in prokaryotes”. In this work, we systematically analyzed gene cassettes from more than 1800 bacterial for the abundance of transcriptional and translational associated genes clustered in distinct gene cassettes. We identified three highly frequent cassettes containing transcriptional and translational genes. Interestingly, each of the three cassettes harbors a gene (nusG, rpsD and nusA) encoding a protein which links transcription and translation in bacteria. Furthermore, our analyses suggest an enrichment of these gene cassettes in pathogenic bacterial phyla.

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Kontakt

Professorship Bioinformatics

Petersgasse 18
94315 Straubing

Head

Prof. Dr. Dominik Grimm

Phone: +49 (0) 9421 187-230
Fax: +49 (0) 9421 187-285
E-Mail: dominik.grimm@hswt.de

Team Assistant

Anna Fischer

Phone: +49 (0) 9421 187-231
Fax: +49 (0) 9421 187-285
E-Mail: anna.fischer@hswt.de

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